Axonal Death And Alzheimer s Disease - 1477 Words

Introduction Axonal death is a main element in many neurodegenerative diseases. It has been observed in many neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Axon degeneration does not necessarily have to involve the typical apoptotic pathway regardless of the morphological similarities to cells undergoing apoptosis. Yang et al. focused on axonal death in traumatic injury because it has been shown to be independent of the necroptotic pathway. This was discovered since treatment with necroptosis inhibitors did not protect axons. To reiterate, axonal death in traumatic injury has commonalities with other diseases such as Alzheimer’s disease and Parkinson’s disease. If there is a greater understanding for the†¦show more content†¦Axonal degeneration does have a significant impact on many neurodegenerative diseases. Their research found that this particular pathway, Sarm1-MAPK pathway, may be a common pathway for differe nt types of axonal degeneration, not just from traumatic injury. If the main pathway or underlying mechanism that drives these diseases is uncovered and understood, then this can lead to creating different methods to protect synapses and axons in these diseases. Other research can focus on trying to inhibit the Sarm1-MAPK pathway, or at least inhibit distinct components within it. Their research is pertinent to finding a cure or possible treatments for many of these diseases. This will have multiple implications on society, medicine, and the quality of life for many people suffering with the many debilitating symptoms associated with these diseases. Experimental System In order to examine axons undergoing degeneration after traumatic injury, they observed axons of retinal ganglion cells (RGCs) in mouse optic nerves. These RGCs were labeled with TdTomato fluorescent protein in order to visualize the axon degeneration following the optic nerve crush—the traumatic injury. Then using the transgenic mouse line, Yang et al. examined the cytosolic version of Nmnat1. In addition, they used wild-type mice that were transduced with TdTomato and a specific shRNA targeting Sarm1Show MoreRelatedAlzheimer s Disease ( Ad )1108 Words   |  5 Pages Alzheimer’s Disease (AD) is a form of dementia that affects 5 million people in the United States alone. One out of every three Seniors die of the disease just in the United States; 80 million suffering world wide making AD the 6th largest cause of death (climax) (Humpel 1; Alzheimer’s Association). AD is the most common dementia; affecting the neuroplasticity of the brain resu lting in physical shrinking of the tissues; thus causing neurodegeneration. 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